It used its depth to outscore the Iowa bench by 36-0, a remarkable edge.
South Carolina is the 10th undefeated team to win the Womens Championship, finishing 38-0.
They won their third national title in seven tournaments and second in three seasons.
Chloe Kitts #21 of the South Carolina Gamecocks shoots over the Iowa HawkeyesThien-An Truong/ISI Photos/Getty Images
South Carolina tied Baylor and Stanford for the third-most championships all-time.
She had a record 18 points in the first quarter, but went just 5 of 20 after that.
She now moves on to the WNBA, where she is the presumptive No.
1 pick of its draft.
Center Kamilla Cardoso of South Carolina had 15 points and 17 rebounds, dominating inside.
She won the Most Outstanding Player award for her efforts.